Immunogen sequence: DIHWLILVTGY LLADDTQGET PLIPPEIMEY SIKHSSEVDI NTTLQILGSP GEKASSIPGY NRTDSVIRLL SAILRVSEVE SRAIRADLTH LLSPQMG
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.
Nuclear transport receptors of karyopherin/importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-4 is a novel mammalian member of this family. It is a RanGTP-binding protein consisting of N-terminal RanGTP-binding motif. It functions as a nuclear export receptor for eIF-5A and also might function as an export adapter in RNA export. It is also involved in nuclear export of Smad3 and regulation of Smad signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Exp4; Exportin-4; FLJ13046; KIAA1721
Gene Aliases: exp4; KIAA1721; XPO4
UniProt ID: (Human) Q9C0E2
Entrez Gene ID: (Human) 64328
Molecular Function: transfer/carrier protein