Immunogen sequence: RFVWNFFRLE NEHLNNCGEF RAVRDISVAP LNADDQTLLE QMMDQDDGVR NRQKNRSWKY NQSISLRRPR LASQSKARDT KVLIEDTDDE ANT
ESTs for Xenotropic And Polytropic Retrovirus Receptor (XPR1) have been isolated from brain, breast, kidney, pancreas, placenta, prostate, skeletal muscle, testis, and tonsil libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
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Protein Aliases: Protein SYG1 homolog; SYG1; X-receptor; X3; Xenotropic and polytropic murine leukemia virus receptor X3; Xenotropic and polytropic retrovirus receptor 1
Gene Aliases: IBGC6; SYG1; X3; XPR1; XR
UniProt ID: (Human) Q9UBH6
Entrez Gene ID: (Human) 9213