PA5-29359 targets XRCC1 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29359 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 281 of Human XRCC1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
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Protein Aliases: complementing defective; DNA repair protein XRCC1; RCC; repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 1; x-ray repair cross-complementing group 1 protein; X-ray repair cross-complementing protein 1; X-ray-repair
Gene Aliases: RCC; Xrcc-1; XRCC1