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Invitrogen
XRCC2 Polyclonal Antibody
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FIGURE: 1 / 2
XRCC2 Antibody (PA5-102487) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded XRCC2 in mouse spleen tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with XRCC2 polyclonal antibody (Product # PA5-102487) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-102487
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human XRCC2(Accession O43543), corresponding to amino acid residues Y223-G273.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total XRCC2.
Target Information
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781P0919; DNA repair protein XRCC2; recA/RAD51 family protein; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross complementing protein 2; X-ray repair cross-complementing protein 2
Gene Aliases: 4921524O04Rik; 8030409M04Rik; FANCU; RAD51; RecA; RGD1564823; XRCC2
UniProt ID: (Human) O43543, (Mouse) Q9CX47
Entrez Gene ID: (Human) 7516, (Mouse) 57434, (Rat) 499966
mitotic cell cycle
meiotic DNA recombinase assembly
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
strand displacement
in utero embryonic development
somitogenesis
DNA repair
mitotic recombination
meiotic nuclear division
reciprocal meiotic recombination
response to X-ray
response to ionizing radiation
response to gamma radiation
multicellular organism growth
strand invasion
negative regulation of neuron apoptotic process
positive regulation of neurogenesis
centrosome organization
regulation of fibroblast apoptotic process
DNA recombination
cellular response to DNA damage stimulus
neurogenesis
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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