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XRCC2 Antibody (PA5-119832) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded mouse testis tissue using XRCC2 Polyclonal Antibody (Product # PA5-119832). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the XRCC2 antibody at a dilution of... View More
Product Details
PA5-119832
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human XRCC2 aa 1-200
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2913404
Product Specific Information
Positive Control: Mouse brain tissue lysates, human kidney tissue lysates, mouse testis tissue.
Subcellular Location: Nucleus, centrosome.
Target Information
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781P0919; DNA repair protein XRCC2; recA/RAD51 family protein; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross-complementing protein 2
Gene Aliases: 4921524O04Rik; 8030409M04Rik; FANCU; RAD51; RecA; XRCC2
UniProt ID: (Human) O43543, (Mouse) Q9CX47
Entrez Gene ID: (Human) 7516, (Mouse) 57434
mitotic cell cycle
meiotic DNA recombinase assembly
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
strand displacement
in utero embryonic development
somitogenesis
DNA repair
mitotic recombination
meiotic nuclear division
reciprocal meiotic recombination
response to X-ray
response to ionizing radiation
response to gamma radiation
multicellular organism growth
strand invasion
negative regulation of neuron apoptotic process
positive regulation of neurogenesis
centrosome organization
regulation of fibroblast apoptotic process
DNA recombination
cellular response to DNA damage stimulus
neurogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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