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XRCC4 Polyclonal Antibody

XRCC4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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XRCC4 Antibody (15817-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 15817-1-AP (XRCC4 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

XRCC4 Antibody in Immunoprecipitation (IP)

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Product Details

15817-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

XRCC4 Fusion Protein Ag8606 (6-310 aa encoded by BC005259)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SRIHLVSEP SITHFLQVSW EKTLESGFVI TLTDGHSAWT GTVSESEISQ EADDMAMEKG KYVGELRKAL LSGAGPADVY TFNFSKESCY FFFEKNLKDV SFRLGSFNLE KVENPAEVIR ELICYCLDTI AENQAKNEHL QKENERLLRD WNDVQGRFEK CVSAKEALET DLYKRFILVL NEKKTKIRSL HNKLLNAAQE REKDIKQEGE TAICSEMTAD RDPVYDESTD EESENQTDLS GLASAAVSKD DSIISSLDVT DIAPSRKRRQ RMQRNLGTEP KMAPQENQLQ EKEKGRKKET SEKEAV (6-310 aa encoded by B C005259)

Target Information

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Significant value of XRCC2 and XRCC9 expression in the prognosis of human ovarian carcinoma.

Journal of Cancer

Liu Y,Xu Y,Jiang M,Chen W,Zhu X

Tue Sep 21 00:00:00 UTC 2021

Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.

Nature communications

Guo G,Gao M,Gao X,Zhu B,Huang J,Tu X,Kim W,Zhao F,Zhou Q,Zhu S,Wu Z,Yan Y,Zhang Y,Zeng X,Zhu Q,Yin P,Luo K,Sun J,Deng M,Lou Z

Mon Apr 12 00:00:00 UTC 2021

Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining.

Cancer research

Zhou Q,Howard ME,Tu X,Zhu Q,Denbeigh JM,Remmes NB,Herman MG,Beltran CJ,Yuan J,Greipp PT,Boughey JC,Wang L,Johnson N,Goetz MP,Sarkaria JN,Lou Z,Mutter RW

Tue Jun 15 00:00:00 UTC 2021

LRIK interacts with the Ku70-Ku80 heterodimer enhancing the efficiency of NHEJ repair.

Cell death and differentiation

Wang D,Zhou Z,Wu E,Ouyang C,Wei G,Wang Y,He D,Cui Y,Zhang D,Chen X,Reed SH,Luo J,Chen R

Tue Dec 01 00:00:00 UTC 2020

RNase L facilitates the repair of DNA double-strand breaks through the nonhomologous end-joining pathway.

FEBS letters

Zhong Y,Pan B,Zhu J,Fu H,Zheng X

Sat Jun 01 00:00:00 UTC 2019

Silencing of XRCC4 increases radiosensitivity of triple-negative breast cancer cells.

Bioscience reports

Wen Y,Dai G,Wang L,Fu K,Zuo S

Fri Mar 29 00:00:00 UTC 2019

Silencing of XRCC4 increases radiosensitivity of triple-negative breast cancer cells.

Bioscience reports

Wen Y,Dai G,Wang L,Fu K,Zuo S

Fri Mar 29 00:00:00 UTC 2019

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation.

PloS one

Jiang W,Li YQ,Liu N,Sun Y,He QM,Jiang N,Xu YF,Chen L,Ma J

Thu Dec 17 00:00:00 UTC 2015

5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation.

PloS one

Jiang W,Li YQ,Liu N,Sun Y,He QM,Jiang N,Xu YF,Chen L,Ma J

Thu Dec 17 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: DNA repair protein XRCC4; hXRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4

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Gene Aliases: SSMED; XRCC4

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UniProt ID: (Human) Q13426

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Entrez Gene ID: (Human) 7518, (Rat) 309995

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Function(s)

DNA binding protein binding protein C-terminus binding ligase activity molecular_function DNA metabolism protein nucleic acid metabolism protein

Process(es)

double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination response to X-ray protein sumoylation DNA ligation involved in DNA repair positive regulation of ligase activity cellular response to lithium ion establishment of integrated proviral latency in utero embryonic development pro-B cell differentiation DNA ligation central nervous system development response to ionizing radiation response to gamma radiation T cell differentiation in thymus V(D)J recombination immunoglobulin V(D)J recombination negative regulation of neuron apoptotic process isotype switching positive regulation of fibroblast proliferation positive regulation of neurogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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XRCC4 Polyclonal Antibody

XRCC4 Antibody (15817-1-AP) in IHC (P)

Product Details

15817-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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