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Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
XRCC4 Fusion Protein Ag8606 (6-310 aa encoded by BC005259) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.28 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: SRIHLVSEP SITHFLQVSW EKTLESGFVI TLTDGHSAWT GTVSESEISQ EADDMAMEKG KYVGELRKAL LSGAGPADVY TFNFSKESCY FFFEKNLKDV SFRLGSFNLE KVENPAEVIR ELICYCLDTI AENQAKNEHL QKENERLLRD WNDVQGRFEK CVSAKEALET DLYKRFILVL NEKKTKIRSL HNKLLNAAQE REKDIKQEGE TAICSEMTAD RDPVYDESTD EESENQTDLS GLASAAVSKD DSIISSLDVT DIAPSRKRRQ RMQRNLGTEP KMAPQENQLQ EKEKGRKKET SEKEAV (6-310 aa encoded by B C005259)
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA repair protein XRCC4; hXRCC4; Protein XRCC4, C-terminus; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4/C
Gene Aliases: SSMED; XRCC4
UniProt ID: (Human) Q13426
Entrez Gene ID: (Human) 7518, (Rat) 309995
Molecular Function:
DNA metabolism protein
nucleic acid metabolism protein
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