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Invitrogen
XRCC4 Polyclonal Antibody
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FIGURE: 1 / 2
XRCC4 Antibody (PA5-80240) in IHC (P)
Immunohistochemistry analysis of XRCC4 on paraffin-embedded human intestinal cancer tissue. Sample was incubated with XRCC4 polyclonal antibody (Product# PA5-80240) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) with DAB chromogen method.
Product Details
PA5-80240
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human XRCC4 (49-75aa ESEISQEADDMAMEKGKYVGELRKALL).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: SW620 whole cell, A431 whole cell. IHC: human intestinal cancer tissue.
Target Information
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein XRCC4; hXRCC4; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4; XRCC4
Gene Aliases: hXRCC4; SSMED; XRCC4
UniProt ID: (Human) Q13426
Entrez Gene ID: (Human) 7518
DNA repair
base-excision repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
response to X-ray
immunoglobulin V(D)J recombination
positive regulation of ligase activity
cellular response to lithium ion
positive regulation of phosphatidylserine exposure on apoptotic cell surface
protein localization to site of double-strand break
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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