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Invitrogen
XRCC4 Polyclonal Antibody
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Product Details
PA5-86754
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in Human XRCC4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein XRCC4; hXRCC4; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4; XRCC4
Gene Aliases: 2310057B22Rik; AW413319; AW545101; hXRCC4; SSMED; XRCC4
UniProt ID: (Human) Q13426, (Mouse) Q924T3
Entrez Gene ID: (Human) 7518, (Mouse) 108138
DNA repair
base-excision repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
response to X-ray
immunoglobulin V(D)J recombination
positive regulation of ligase activity
cellular response to lithium ion
positive regulation of phosphatidylserine exposure on apoptotic cell surface
protein localization to site of double-strand break
in utero embryonic development
pro-B cell differentiation
DNA ligation
central nervous system development
response to ionizing radiation
response to gamma radiation
T cell differentiation in thymus
V(D)J recombination
negative regulation of neuron apoptotic process
isotype switching
positive regulation of fibroblast proliferation
positive regulation of neurogenesis
DNA ligation involved in DNA repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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