Positive Control: HeLa, MCF-7, MDA-MB-231
Predicted Reactivity: Mouse (98%), Rat (98%), Xenopus laevis (81%), Rabbit (100%), Chicken (93%), Sheep (98%), Bovine (100%), Guinea pig (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. It regulates the transcription of numerous genes and promotes separation of DNA strands that contain mismatches or are modified by cisplatin. It has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), and it may play a role in DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BP8; CBF-A; CCAAT-binding transcription factor I subunit A; CSDA2; CSDB; DBPB; DNA-binding protein B; EFI-A; Enhancer factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I; MDR NF1; NSEP1; nuclease sensitive element binding protein 1; Nuclease-sensitive element-binding protein 1; Y box binding protein 1; Y-box binding protein 1; Y-box transcription factor; Y-box-binding protein 1; YB-1; YB1; YBX1
Gene Aliases: BP-8; CBF-A; CSDA2; CSDB; DBPB; EFI-A; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1; YBX1
UniProt ID: (Human) P67809
Entrez Gene ID: (Human) 4904