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Product Details
PA5-27228
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 234 and 531 of Human c-Yes
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2544704
Product Specific Information
Recommended positive controls: A431, Neuro 2A, C8D30, NIH-3T3, Raw264.7, PC-12, Rat2.
Predicted reactivity: Mouse (99%), Zebrafish (95%), Xenopus laevis (97%), Dog (100%), Chicken (97%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
YES1 is a recombinant human protein kinase that is a member of the SRC family of non-receptor tyrosine kinases and is the cellular homolog of the Yamaguchi sarcoma virus oncogene. It is involved in the regulation of cell growth and survival, including roles in apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Src; cellular yes-1 protein; EC 2.7.10.2; p61-Yes; Proto-oncogene c-Yes; proto-oncogene tyrosine-protein kinase YES; Tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; viral oncogene yes homolog; Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1; Yamaguchi sarcoma oncogene; Yamaguchi sarcoma viral oncogene homolog 1; YES1 proto-oncogene, Src family tyrosine kinase
Gene Aliases: c-Yes; HsT441; p60c-yes; P61-YES; YES; YES1
UniProt ID: (Human) P07947, (Mouse) Q04736
Entrez Gene ID: (Human) 7525, (Rat) 24884, (Mouse) 22612
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
epidermal growth factor receptor binding
protein binding
ATP binding
enzyme binding
ion channel binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane receptor protein tyrosine kinase signaling pathway
glucose transport
peptidyl-tyrosine phosphorylation
cell differentiation
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to retinoic acid
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
cellular protein modification process
T cell costimulation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of vascular permeability
ephrin receptor signaling pathway
leukocyte migration
protein phosphorylation
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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