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Proteintech
YTHDF1 Polyclonal Antibody
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Product Details
17479-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
YTHDF1 Fusion Protein Ag11509 (210-559 aa encoded by BC050284)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Amount
39 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VALTGVLSG NGGTNVNMPV SKPTSWAAIA SKPAKPQPKM KTKSGPVMGG GLPPPPIKHN MDIGTWDNKG PVPKAPVPQQ APSPQAAPQP QQVAQPLPAQ PPALAQPQYQ SPQQPPQTRW VAPRNRNAAF GQSGGAGSDS NSPGNVQPNS APSVESHPVL EKLKAAHSYN PKEFEWNLKS GRVFIIKSYS EDDIHRSIKY SIWCSTEHGN KRLDSAFRCM SSKGPVYLLF SVNGSGHFCG VAEMKSPVDY GTSAGVWSQD KWKGKFDVQW IFVKDVPNNQ LRHIRLENND NKPVTNSRDT QEVPLEKAKQ VLKIISSYKH TTSIFDDFAH YEKRQEEEEV VRKERQSRNK Q (210-559 aa encoded by BC050284)
Target Information
Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). Required to facilitate learning and memory formation in the hippocampus by enhancing protein synthesis upon neuronal stimulation: in response to neuronal stimulation, binds to m6A-containing neuronal mRNAs, promoting their translation, thereby contributing to learning and memory. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts, thereby promoting their translation. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells. Acts by binding and promoting translation of m6A-containing transcripts encoding proteins involved in lysosomal degradation and phagosome maturation, leading to increased antigen degradation in myeloid dendritic cells. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DACA-1; DACA-1 homolog; Dermatomyositis associated with cancer putative autoantigen 1; Dermatomyositis associated with cancer putative autoantigen 1 homolog; DF1; unnamed protein product; YTH domain family 1; YTH domain family protein 1; YTH domain family, member 1; YTH domain-containing family protein 1; YTH N(6)-methyladenosine RNA binding protein 1; YTH N6-methyladenosine RNA binding protein 1
Gene Aliases: 2210410K23Rik; 8030473O16; C20orf21; DF1; YTHDF1
UniProt ID: (Human) Q9BYJ9, (Mouse) P59326
Entrez Gene ID: (Human) 54915, (Mouse) 228994, (Rat) 296467
biological_process
immune system process
regulation of antigen processing and presentation
learning
memory
stress granule assembly
regulation of mRNA stability
positive regulation of translation
positive regulation of translational initiation
mRNA destabilization
organelle assembly
regulation of long-term synaptic potentiation
regulation of axon guidance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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