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Proteintech
YY1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
22156-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
YY1 Fusion Protein Ag17792 (1-414 aa encoded by BC037308)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The open reading frame of the human YY1 cDNA encodes a protein of 414 amino acids with a predicted molecular weight of 44 kDa. However, YY1 migrates on SDS gels as a 65-68 kDa protein, probably due to the structure of the protein. It is a ubiquitously expressed transcription factor with fundamental roles in embryogenesis, differentiation, replication, and proliferation. This is a rabbit polyclonal antibody raised against full length YY1 of human origin.
Immunogen sequence: MASGDTLYI ATDGSEMPAE IVELHEIEVE TIPVETIETT VVGEEEEEDD DDEDGGGGDH GGGGGHGHAG HHHHHHHHHH HPPMIALQPL VTDDPTQVHH HQEVILVQTR EEVVGGDDSD GLRAEDGFED QILIPVPAPA GGDDDYIEQT LVTVAAAGKS GGGGSSSSGG GRVKKGGGKK SGKKSYLSGG AGAAGGGGAD PGNKKWEQKQ VQIKTLEGEF SVTMWSSDEK KDIDHETVVE EQIIGENSPP DYSEYMTGKK LPPGGIPGID LSDPKQLAEF ARMKPRKIKE DDAPRTIACP HKGCTKMFRD NSAMRKHLHT HGPRVHVCAE CGKAFVESSK LKRHQLVHTG EKPFQCTFEG CGKRFSLDFN LRTHVRIHTG DRPYVCPFDG CNKKFAQSTN LKSHILTHAK AKNNQ (1-414 aa encoded by BC037308)
Target Information
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: delta transcription factor; INO80 complex subunit S; UCR-motif DNA-binding protein; UCRBP transcription factor; unnamed protein product; yin and yang 1; Yin and Yang 1 protein; Yin Yang 1; YY-1
Gene Aliases: DELTA; GADEVS; INO80S; NF-E1; UCRBP; YIN-YANG-1; YY-1
UniProt ID: (Human) P25490, (Mouse) Q00899
Entrez Gene ID: (Human) 7528, (Mouse) 22632
four-way junction DNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA binding
protein binding
sequence-specific DNA binding
SMAD binding
lncRNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
telomere maintenance
double-strand break repair via homologous recombination
regulation of DNA replication
regulation of DNA repair
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
RNA localization
cellular response to DNA damage stimulus
mitochondrion organization
spermatogenesis
anterior/posterior pattern specification
response to UV-C
gene expression
positive regulation of gene expression
negative regulation of gene expression
B cell differentiation
negative regulation of interferon-beta production
regulation of chromosome organization
cellular response to UV
response to prostaglandin F
regulatory T cell differentiation
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
cell development
camera-type eye morphogenesis
chromosome organization
regulation of cell cycle
regulation of DNA strand elongation
negative regulation of cell growth involved in cardiac muscle cell development
cellular response to interleukin-1
immunoglobulin heavy chain V-D-J recombination
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of telomere maintenance in response to DNA damage
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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