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Proteintech
YY1 Polyclonal Antibody
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Product Details
22156-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
YY1 Fusion Protein Ag17792 (1-414 aa encoded by BC037308)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The open reading frame of the human YY1 cDNA encodes a protein of 414 amino acids with a predicted molecular weight of 44 kDa. However, YY1 migrates on SDS gels as a 65-68 kDa protein, probably due to the structure of the protein. It is a ubiquitously expressed transcription factor with fundamental roles in embryogenesis, differentiation, replication, and proliferation. This is a rabbit polyclonal antibody raised against full length YY1 of human origin.
Immunogen sequence: MASGDTLYI ATDGSEMPAE IVELHEIEVE TIPVETIETT VVGEEEEEDD DDEDGGGGDH GGGGGHGHAG HHHHHHHHHH HPPMIALQPL VTDDPTQVHH HQEVILVQTR EEVVGGDDSD GLRAEDGFED QILIPVPAPA GGDDDYIEQT LVTVAAAGKS GGGGSSSSGG GRVKKGGGKK SGKKSYLSGG AGAAGGGGAD PGNKKWEQKQ VQIKTLEGEF SVTMWSSDEK KDIDHETVVE EQIIGENSPP DYSEYMTGKK LPPGGIPGID LSDPKQLAEF ARMKPRKIKE DDAPRTIACP HKGCTKMFRD NSAMRKHLHT HGPRVHVCAE CGKAFVESSK LKRHQLVHTG EKPFQCTFEG CGKRFSLDFN LRTHVRIHTG DRPYVCPFDG CNKKFAQSTN LKSHILTHAK AKNNQ (1-414 aa encoded by BC037308)
Target Information
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Delta transcription factor; INO80 complex subunit S; NF-E1; Transcriptional repressor protein YY1; UCR-motif DNA-binding protein; UCRBP transcription factor; Yin and yang 1; Yin and Yang 1 protein; Yin Yang 1; YY-1
Gene Aliases: AW488674; DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1; YY1
UniProt ID: (Human) P25490, (Mouse) Q00899
Entrez Gene ID: (Human) 7528, (Mouse) 22632
four-way junction DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
enhancer sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
RNA binding
protein binding
zinc ion binding
transcription regulatory region DNA binding
SMAD binding
nucleic acid binding
histone deacetylase binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
spermatogenesis
response to UV-C
negative regulation of gene expression
cell differentiation
cellular response to UV
DNA repair
DNA recombination
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
RNA localization
anterior/posterior pattern specification
positive regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
camera-type eye morphogenesis
chromosome organization
cellular response to interleukin-1
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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