Immunogen sequence: MSSLGASFV QIKFDDLQFF ENCGGGSFGS VYRAKWISQD KEVAVKKLLK IEKEAEILSV LSHRNIIQFY GVILEPPNYG IVTEYASLGS LYDYINSNRS EEMDMDHIMT WATDVAKGMH YLHMEAPVKV IHRDLKSRNV VIAADGVLKI CDFGASRFHN HTTHMSLVGT FPWMAPEVIQ SLPVSETCDT YSYGVVLWEM LTREVPFKGL EGLQVAWLVV EKNERLTIPS SCPRSFAELL HQCWEADAKK RPSFKQIISI LESMSNDTSL PDKCNSFLHN KAEWRCEIEA TLERLKKLER DLSFKEQELK ERE (1-312 aa encoded by BC001401)
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: HCCS-4; Human cervical cancer suppressor gene 4 protein; Leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase-related kinase; mixed lineage kinase-related kinase MRK-beta; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MRK; sterile alpha motif and leucine zipper containing kinase AZK; Sterile alpha motif- and leucine zipper-containing kinase AZK; sterile-alpha motif and leucine zipper containing kinase AZK
Gene Aliases: HCCS4; MAP3K20; MLTK; ZAK