Bethyl Laboratories

ZBTB1 Polyclonal Antibody

View all (7) ZBTB1 antibodies

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ZBTB1 Antibody in Western Blot (WB) — Detection of human and mouse ZBTB1 by western blot. Samples: Whole cell lysate from HeLa (15 and 50 µg), Jurkat (J; 50 µg), 293T (T; 50 µg) and mouse NIH3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-ZBTB1 antibody A303-242A used for WB at 0.4 µg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Product Details

A303-242A

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:5,000	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Between 663 and 713
Conjugate	Unconjugated
Form	liquid
Concentration	1 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	tris citrate/phosphate, pH 7-8
Contains	0.09% sodium azide
Storage conditions	4° C

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

ZBTB1 acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain specific protein 2; Zinc finger and BTB domain-containing protein 1

Gene Aliases: 9430077A12; AI256369; Bsg2; C430003J21Rik; KIAA0997; ZBTB1; ZNF909

UniProt ID: (Human) Q9Y2K1, (Mouse) Q91VL9

Entrez Gene ID: (Human) 22890, (Mouse) 268564

Molecular Function: C2H2 zinc finger transcription factor

negative regulation of transcription from RNA polymerase II promoter positive regulation of T cell mediated immunity DNA repair chromatin remodeling cellular response to DNA damage stimulus translesion synthesis B cell differentiation positive regulation of natural killer cell differentiation T cell differentiation in thymus cellular response to UV mRNA transcription from RNA polymerase II promoter innate immune response positive regulation of T cell differentiation thymus development protein homooligomerization positive regulation of pro-T cell differentiation immune system process transcription, DNA-templated regulation of transcription, DNA-templated cell differentiation

Process(es)

DNA binding protein binding protein homodimerization activity metal ion binding protein heterodimerization activity K63-linked polyubiquitin binding nucleic acid binding