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ZBTB1 acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: brain specific protein 2; Zinc finger and BTB domain-containing protein 1
Gene Aliases: 9430077A12; AI256369; Bsg2; C430003J21Rik; KIAA0997; ZBTB1; ZNF909
UniProt ID: (Human) Q9Y2K1, (Mouse) Q91VL9
Entrez Gene ID: (Human) 22890, (Mouse) 268564
Molecular Function:
KRAB box transcription factor
transcription factor
zinc finger transcription factor
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