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The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.
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Protein Aliases: expressed in brain and neural tube; RP11-397D12.5; Transcription factor ZNF-POZ; Zinc finger and BTB domain-containing protein 5
Gene Aliases: 5930421I10; 9430083K24Rik; AI646847; KIAA0354; mKIAA0354; ZBTB5
UniProt ID: (Human) O15062, (Mouse) Q7TQG0
Entrez Gene ID: (Human) 9925, (Mouse) 230119, (Rat) 298084
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