Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
25009-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZC3H12A Fusion Protein Ag13877 (339-599 aa encoded by BC005001)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.48 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: ANALLSPPR APSKDKNGRR PSPSSQSSSL LTESEQCSLD GKKLGAQASP GSRQEGLTQT YAPSGRSLAP SGGSGSSFGP TDWLPQTLDS LPYVSQDCLD SGIGSLESQM SELWGVRGGG PGEPGPPRAP YTGYSPYGSE LPATAAFSAF GRAMGAGHFS VPADYPPAPP AFPPREYWSE PYPLPPPTSV LQEPPVQSPG AGRSPWGRAD SLAKEQASVY TKLCGVFPPH LVEAVMGRFP QLLDPQQLAA EILSYKSQHP SE (339-599 aa encoded by BC005001)
Target Information
ZC3H12A is an MCP1 -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Endoribonuclease ZC3H12A; MCP-1 treatment-induced protein; MCP-induced protein 1; Monocyte chemotactic protein-induced protein 1; Reg1; Regnase-1; ribonuclease ZC3H12A; RP3-423B22.1; zc3h12a; Zinc finger CCCH domain-containing protein 12A
Gene Aliases: BC036563; dJ423B22.1; MCPIP; MCPIP1; ZC3H12A
UniProt ID: (Human) Q5D1E8, (Mouse) Q5D1E7
Entrez Gene ID: (Human) 80149, (Mouse) 230738
Molecular Function:
endoribonuclease
nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
angiogenesis
negative regulation of protein phosphorylation
positive regulation of defense response to virus by host
transcription, DNA-templated
apoptotic process
inflammatory response
cellular response to DNA damage stimulus
nervous system development
regulation of gene expression
positive regulation of autophagy
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of gene expression
negative regulation of muscle cell apoptotic process
positive regulation of lipid storage
positive regulation of cell death
protein deubiquitination
cell differentiation
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
cellular response to oxidative stress
cellular response to glucose starvation
positive regulation of protein import into nucleus
negative regulation of NF-kappaB import into nucleus
negative regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation by host of viral genome replication
negative regulation of nitric oxide biosynthetic process
positive regulation of fat cell differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of interleukin-1 beta secretion
protein oligomerization
defense response to virus
negative regulation of cardiac muscle contraction
positive regulation of mRNA catabolic process
3'-UTR-mediated mRNA destabilization
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
RNA phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA phosphodiester bond hydrolysis, exonucleolytic
cellular response to virus
negative regulation of cytokine production involved in inflammatory response
positive regulation of execution phase of apoptosis
negative regulation of interleukin-6 secretion
positive regulation of p38MAPK cascade
negative regulation of interferon-gamma secretion
positive regulation of protein deubiquitination
negative regulation of production of miRNAs involved in gene silencing by miRNA
cellular response to sodium arsenite
negative regulation of tumor necrosis factor secretion
cellular response to phorbol 13-acetate 12-myristate
cellular response to ionomycin
cellular response to chemokine
positive regulation of reactive oxygen species metabolic process
positive regulation of miRNA catabolic process
multicellular organism development
DNA binding
chromatin binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
endoribonuclease activity
exoribonuclease activity
ribonuclease activity
thiol-dependent ubiquitin-specific protease activity
protein binding
miRNA binding
RNA stem-loop binding
mRNA 3'-UTR AU-rich region binding
ribosome binding
metal ion binding
nuclease activity
endonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support