The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; CCCH-type zinc finger antiviral protein (Zap); Inactive Poly [ADP-ribose] polymerase 13; PARP13; rZAP; ZAP; Zinc finger antiviral protein; Zinc finger CCCH domain-containing protein 2; Zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type, antiviral 1
Gene Aliases: 1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik; ARTD13; D6Bwg1452e; FLB6421; PARP13; PRO1677; ZAP; ZC3H2; ZC3HAV1; ZC3HDC2
Molecular Function: nucleic acid binding