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Proteintech
ZC3HAV1 Polyclonal Antibody
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Product Details
16820-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZC3HAV1 Fusion Protein Ag10364 (1-351 aa encoded by BC025308)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Amount
55.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MADPEVCCF ITKILCAHGG RMALDALLQE IALSEPQLCE VLQVAGPDRF VVLETGGEAG ITRSVVATTR ARVCRRKYCQ RPCDNLHLCK LNLLGRCNYS QSERNLCKYS HEVLSEENFK VLKNHELSGL NKEELAVLLL QSDPFFMPEI CKSYKGEGRQ QICNQQPPCS RLHICDHFTR GNCRFPNCLR SHNLMDRKVL AIMREHGLNP DVVQNIQDIC NSKHMQKNPP GPRAPSSHRR NMAYRARSKS RDRFFQGSQE FLASASASAE RSCTPSPDQI SHRASLEDAP VDDLTRKFTY LGSQDRARPP SGSSKATDLG GTSQAGTSQR FLENGSQEDL LHGNPGSTYL AS (1-351 aa encoded by BC025308)
Target Information
The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; CCCH-type zinc finger antiviral protein (Zap); Inactive Poly [ADP-ribose] polymerase 13; PARP-13; PARP13; predicted protein of HQ1677; rZAP; unnamed protein product; ZAP; Zinc finger antiviral protein; Zinc finger CCCH domain-containing protein 2; Zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type, antiviral 1
Gene Aliases: 1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik; ARTD13; D6Bwg1452e; FLB6421; PARP13; PRO1677; ZAP; ZC3H2; ZC3HAV1; ZC3HDC2
UniProt ID: (Human) Q7Z2W4, (Mouse) Q3UPF5
Entrez Gene ID: (Human) 56829, (Rat) 252832, (Mouse) 78781
response to virus
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
suppression by virus of host molecular function
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of viral genome replication
innate immune response
regulation of defense response to virus by host
defense response to virus
positive regulation of mRNA catabolic process
cellular response to exogenous dsRNA
positive regulation of RIG-I signaling pathway
immune system process
positive regulation of ATPase activity
protein poly-ADP-ribosylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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