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Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHC-type containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.
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Protein Aliases: DHHC domain-containing cysteine-rich protein 18; DHHC-18; membrane-associated DHHC18 zinc finger protein; Palmitoyltransferase ZDHHC18; Zinc finger DHHC domain-containing protein 18; zinc finger, DHHC domain containing 18; zinc finger, DHHC-type containing 18
Gene Aliases: DHHC-18; DHHC18; ZDHHC18