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Invitrogen
ZDHHC2 Polyclonal Antibody
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FIGURE: 1 / 4
ZDHHC2 Antibody (PA5-25504) in IHC (P)
Immunohistochemistry analysis of ZDHHC2 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with ZDHHC2 polyclonal antibody (Product # PA5-25504) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-25504
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 77-106 amino acids of human ZDHC2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses. In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors. Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons. Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyltransferase ZDHHC2; DHHC-2; Palmitoyltransferase ZDHHC2; Ream; Rec; Reduced expression associated with metastasis protein; Reduced expression in cancer protein; testis tissue sperm-binding protein Li 56e; unnamed protein product; Zinc finger DHHC domain-containing protein 2; zinc finger DHHC-type containing 2; zinc finger DHHC-type palmitoyltransferase 2; Zinc finger protein 372; zinc finger, DHHC domain containing 2
Gene Aliases: 5730415P04Rik; 6430583A19Rik; DHHC2; REAM; REC; ZDHHC2; ZNF372
UniProt ID: (Human) Q9UIJ5, (Mouse) P59267
Entrez Gene ID: (Human) 51201, (Mouse) 70546
palmitoyltransferase activity
transferase activity
transferase activity, transferring acyl groups
protein-cysteine S-myristoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
protein homodimerization activity
protein-cysteine S-stearoyltransferase activity
zinc ion binding
metal ion binding
protein targeting to membrane
synapse assembly
synaptic vesicle maturation
peptidyl-L-cysteine S-palmitoylation
regulation of cell-cell adhesion
regulation of protein catabolic process
regulation of neuronal synaptic plasticity
protein localization to plasma membrane
regulation of postsynaptic neurotransmitter receptor diffusion trapping
positive regulation of long-term synaptic potentiation
protein localization to membrane raft
regulation of protein localization to plasma membrane
protein localization to postsynaptic membrane
positive regulation of AMPA glutamate receptor clustering
positive regulation of endosome to plasma membrane protein transport
protein palmitoylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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