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ZDHHC3 Polyclonal Antibody
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Product Details
BS-12034R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ZDHHC3, amino acids 230-327.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo. Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyltransferase ZDHHC3; DHHC-3; DHHC1 protein; GABA-A receptor-associated membrane protein 1; Golgi apparatus-specific protein with DHHC zinc finger domain; Golgi-specific DHHC zinc finger protein; Palmitoyltransferase ZDHHC3; Protein DHHC1; unnamed protein product; Zinc finger DHHC domain-containing protein 3; zinc finger DHHC-type containing 3; zinc finger DHHC-type palmitoyltransferase 3; zinc finger protein 373; zinc finger, DHHC domain containing 3
Gene Aliases: 1110020O22Rik; 1810006O10Rik; 2210017C02Rik; DHHC-3; DHHC3; GODZ; Gramp1; HSD49; ZDHHC3; Zfp373; ZNF373
UniProt ID: (Human) Q9NYG2, (Mouse) Q8R173, (Rat) Q2TGK3
Entrez Gene ID: (Human) 51304, (Mouse) 69035, (Rat) 301081
palmitoyltransferase activity
transferase activity
transferase activity, transferring acyl groups
protein-cysteine S-myristoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
protein homodimerization activity
protein-cysteine S-stearoyltransferase activity
zinc ion binding
metal ion binding
protein targeting
protein palmitoylation
protein targeting to membrane
regulation of G-protein coupled receptor protein signaling pathway
peptidyl-L-cysteine S-palmitoylation
cellular response to nutrient levels
positive regulation of synaptic transmission, GABAergic
toll-like receptor 9 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
TRAIL-activated apoptotic signaling pathway
lipoprotein localization to membrane
protein localization to membrane
protein localization to plasma membrane
positive regulation of protein localization to lysosome
positive regulation of receptor localization to synapse
protein localization to photoreceptor outer segment
positive regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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