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Invitrogen
ZEB1 Polyclonal Antibody
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Product Details
PA5-96366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human ZEB1 (NP_1103783)
Conjugate
Form
Liquid
Concentration
2.08 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: INIAIPTVTA QLPTIVAIAD QNSVPCLRAL AANKQTILIP QVAYTYSTTV SPAVQEPPLK VIQPNGNQDE RQDTSSEGVS NVEDQNDSDS TPPKKKMRKT E
Positive Samples: SKOV3, HeLa; Cellular Location: Nucleus
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Delta EF1; delta-crystallin enhancer binding factor 1; DELTA-EF1; MEB1; MGC133261; Negative regulator of IL2; NIL-2-A; NIL-2-A zinc finger protein; NIL-2A; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; RP11-472N13.4; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); twirler; Zfhep; Zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; Zinc finger homeodomain enhancer-binding protein
Gene Aliases: 3110032K11Rik; [delta]EF1; AREB6; BZP; DELTAEF1; FECD6; MEB1; Nil2; NIL2A; PPCD3; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZFHEP; ZFHX1A; Zfx1a; Zfx1ha
UniProt ID: (Human) P37275, (Mouse) Q64318, (Rat) Q62947
Entrez Gene ID: (Human) 6935, (Mouse) 21417, (Rat) 25705
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
transcription factor binding
zinc ion binding
E-box binding
nucleic acid binding
DNA binding
double-stranded DNA binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
immune response
pattern specification process
central nervous system development
cell proliferation
negative regulation of cell proliferation
regulation of mesenchymal cell proliferation
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell differentiation
regulation of T cell differentiation in thymus
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
embryonic skeletal system morphogenesis
semicircular canal morphogenesis
regulation of smooth muscle cell differentiation
cartilage development
cellular response to amino acid stimulus
cochlea morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
cell differentiation
animal organ development
embryonic morphogenesis
response to activity
forebrain development
response to nutrient levels
cellular response to transforming growth factor beta stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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