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Invitrogen
ZEB2 Polyclonal Antibody
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.jpg?time=20220826?time=20220826 "ZEB2 Antibody (PA5-20980) in WB")
Product Details
PA5-20980
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the carboxy terminus of human ZEB2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Due to post-translational modifications, ZEB2 migrates at ~180kDa in SDS-PAGE. A suggested positive control is Jurkat cell lysate.
PA5-20980 can be used with blocking peptide PEP-1094.
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b
Gene Aliases: 9130203F04Rik; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; SIP-1; SIP1; SMADIP1; ZEB2; ZFHX1B; ZFX1B; Zfxh1b
UniProt ID: (Human) O60315, (Mouse) Q9R0G7
Entrez Gene ID: (Human) 9839, (Mouse) 24136, (Rat) 311071
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
phosphatase regulator activity
metal ion binding
R-SMAD binding
nucleic acid binding
molecular_function
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
somitogenesis
neural tube closure
transcription from RNA polymerase II promoter
nervous system development
corpus callosum morphogenesis
hippocampus development
cell proliferation in forebrain
corticospinal tract morphogenesis
positive regulation of Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of melanocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of melanin biosynthetic process
developmental pigmentation
collateral sprouting
positive regulation of axonogenesis
mammillary axonal complex development
melanocyte migration
positive regulation of lens fiber cell differentiation
regulation of melanosome organization
transcription, DNA-templated
regulation of transcription, DNA-templated
central nervous system development
embryonic morphogenesis
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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