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Invitrogen

ZEB2 Polyclonal Antibody

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ZEB2 Polyclonal Antibody

Product Details

PA5-95090

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
- -

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ZEB2 (948-962aa DMQQRRKYQRKQGFQ).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806896

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human HEL whole cell, human MCF-7 whole cell. IHC: mouse brain tissue, rat brain tissue, human glioma tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HRIHFB2411; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; unnamed protein product; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b

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Gene Aliases: 9130203F04Rik; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; SIP-1; SIP1; SMADIP1; ZEB2; ZFHX1B; ZFX1B; Zfxh1b

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UniProt ID: (Human) O60315, (Mouse) Q9R0G7

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Entrez Gene ID: (Human) 9839, (Mouse) 24136, (Rat) 311071

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding zinc ion binding phosphatase regulator activity metal ion binding R-SMAD binding nucleic acid binding molecular_function C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter neural crest cell migration somitogenesis neural tube closure endothelial cell proliferation regulation of transcription from RNA polymerase II promoter nervous system development central nervous system development negative regulation of fibroblast migration corpus callosum morphogenesis hippocampus development cell proliferation in forebrain corticospinal tract morphogenesis positive regulation of Wnt signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway myofibroblast differentiation stress fiber assembly endothelial cell migration positive regulation of melanocyte differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of melanin biosynthetic process developmental pigmentation astrocyte activation embryonic morphogenesis collateral sprouting positive regulation of axonogenesis mammillary axonal complex development pyroptosis fibroblast activation positive regulation of canonical Wnt signaling pathway response to oxygen-glucose deprivation melanocyte migration positive regulation of lens fiber cell differentiation regulation of melanosome organization positive regulation of myofibroblast contraction regulation of myofibroblast cell apoptotic process regulation of blood-brain barrier permeability transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of JUN kinase activity biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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