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Proteintech
ZFP36 Polyclonal Antibody
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Product Details
12737-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZFP36 Fusion Protein Ag3461 (1-326 aa encoded by BC009693)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDLTAIYES LLSLSPDVPV PSDHGGTESS PGWGSSGPWS LSPSDSSPSG VTSRLPGRST SLVEGRSCGW VPPPPGFAPL APRLGPELSP SPTSPTATST TPSRYKTELC RTFSESGRCR YGAKCQFAHG LGELRQANRH PKYKTELCHK FYLQGRCPYG SRCHFIHNPS EDLAAPGHPP VLRQSISFSG LPSGRRTSPP PPGLAGPSLS SSSFSPSSSP PPPGDLPLSP SAFSAAPGTP LARRDPTPVC CPSCRRATPI SVWGPLGGLV RTPSVQSLGS DPDEYASSGS SLGGSDSPVF EAGVFAPPQP VAAPRRLPIF NRISVSE (1-326 aa encoded by BC009693)
Target Information
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G0/G1 switch regulatory protein 24; Growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; TPA-induced sequence 11; Tristetraprolin; tristetraproline; TTP; unnamed protein product; Zfp-36; Zinc finger protein 36; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog
Gene Aliases: G0S24; GOS24; NUP475; RNF162A; TIS11; TIS11A; TIS11D; TISII; TTP; Zfp-36; ZFP36
UniProt ID: (Human) P26651, (Mouse) P22893, (Rat) P47973
Entrez Gene ID: (Human) 7538, (Mouse) 22695, (Rat) 79426
DNA binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
protein binding
zinc ion binding
enzyme binding
protein kinase binding
C-C chemokine binding
heat shock protein binding
mRNA 3'-UTR AU-rich region binding
macromolecular complex binding
metal ion binding
RNA polymerase binding
14-3-3 protein binding
protein-RNA sequence-specific adaptor activity
AU-rich element binding
poly(A) RNA binding
RNA metabolism protein
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
mRNA catabolic process
response to wounding
regulation of keratinocyte proliferation
gene silencing by RNA
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
regulation of tumor necrosis factor production
negative regulation of interleukin-2 production
negative regulation of viral transcription
miRNA mediated inhibition of translation
p38MAPK cascade
response to starvation
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
positive regulation of fat cell differentiation
regulation of keratinocyte differentiation
negative regulation of erythrocyte differentiation
mRNA transport
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
3'-UTR-mediated mRNA destabilization
3'-UTR-mediated mRNA stabilization
cellular response to lipopolysaccharide
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of cytokine production involved in inflammatory response
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
regulation of keratinocyte apoptotic process
negative regulation of polynucleotide adenylyltransferase activity
positive regulation of intracellular mRNA localization
negative regulation of 3'-UTR-mediated mRNA stabilization
positive regulation of gene silencing by miRNA
regulation of transcription from RNA polymerase II promoter
intracellular signal transduction
negative regulation of myeloid cell differentiation
negative regulation of inflammatory response
RNA destabilization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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