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Fabgennix
ZFP36L2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
ZFP36L2-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid reigon 350-400 on human Zinc finger protein 36, C3H1 type-like 2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5'UUAUUUAUUU-3' core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: butyrate response factor 2; butyrate response factor 2 (EGF-response factor 2); EGF-response factor 2; ERF-2; Protein TIS11D; TIS11d(del); TIS11d(ins); TISD; TPA-induced sequence 11d; unnamed protein product; ZFP36 ring finger protein like 2; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; zinc finger protein 36, C3H1 type-like 2; zinc finger protein 36, C3H1 type-like 2-like; zinc finger protein, C3H type, 36-like 2
Gene Aliases: BRF2; ERF-2; ERF2; OOMD13; OZEMA13; RNF162C; TIS11D
UniProt ID: (Human) P47974, (Mouse) P23949
Entrez Gene ID: (Human) 678, (Mouse) 12193, (Rat) 298765
MAPK cascade
nuclear-transcribed mRNA poly(A) tail shortening
mRNA catabolic process
response to wounding
negative regulation of translation
hemopoiesis
T cell differentiation in thymus
somatic stem cell population maintenance
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
regulation of B cell differentiation
negative regulation of fat cell differentiation
somatic stem cell division
definitive hemopoiesis
3'-UTR-mediated mRNA destabilization
ERK1 and ERK2 cascade
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of mitotic cell cycle phase transition
negative regulation of stem cell differentiation
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of gene expression
positive regulation of mRNA catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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