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Proteintech
ZFPM1 Polyclonal Antibody
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Product Details
28012-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MTKANCERHL KVHTDTLSGV CHSCGFISTT RDILYSHLVT NHMVCQPGSK GEIYSPGAGH PATKLPPDSL GSFQQQHTAL QGPLASADLG LAPTPSPGLD RKALAEATNG EARAEPLAQN GGSSEPPAAP RSIKVEAVEE PEAAPILGPG EPGPQAPSRT PSPRSPAPAR VKAELSS
Target Information
ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FOG-1; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA-1; Zinc finger protein 89A; Zinc finger protein multitype 1; Zinc finger protein ZFPM1; zinc finger protein, multitype 1
Gene Aliases: FOG; FOG1; ZC2HC11A; ZFN89A; ZFPM1; ZNF408; ZNF89A
UniProt ID: (Human) Q8IX07, (Mouse) O35615
Entrez Gene ID: (Human) 161882, (Rat) 691504, (Mouse) 22761
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
protein binding
transcription factor binding
metal ion binding
nucleic acid binding
DNA binding
transcription corepressor activity
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
T-helper cell lineage commitment
outflow tract morphogenesis
atrioventricular valve morphogenesis
mitral valve formation
tricuspid valve formation
transcription, DNA-templated
heart development
blood coagulation
regulation of definitive erythrocyte differentiation
erythrocyte differentiation
megakaryocyte differentiation
platelet formation
granulocyte differentiation
negative regulation of protein binding
regulation of chemokine production
embryonic hemopoiesis
megakaryocyte development
positive regulation of interferon-gamma biosynthetic process
negative regulation of interleukin-4 biosynthetic process
negative regulation of fat cell differentiation
cardiac muscle tissue morphogenesis
definitive erythrocyte differentiation
primitive erythrocyte differentiation
negative regulation of mast cell differentiation
ventricular septum morphogenesis
atrial septum morphogenesis
transcriptional activation by promoter-enhancer looping
positive regulation of transcription from RNA polymerase II promoter
homeostasis of number of cells
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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