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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.04-0.4 µg/mL | - |
Immunohistochemistry (IHC) |
1:1,000-1:2,500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Human ZFYVE19 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.9 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2664422 |
Immunogen sequence: SGCLSFSAAVP RTGNTQQKVC KQCHEVLTRG SSANASKWSP PQNYKKRVAA LEAKQKPSTS QSQGLTRQDQ MIAERLARLR QENKPKLVPS Q
Highest antigen sequence identity to the following orthologs - mouse 85%, rat 85%.
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Abscission/NoCut checkpoint regulator; ANCHR; MLL partner containing FYVE domain; Zinc finger FYVE domain-containing protein 19; zinc finger, FYVE domain containing 19
Gene Aliases: ANCHR; MPFYVE; ZFYVE19
UniProt ID: (Human) Q96K21
Entrez Gene ID: (Human) 84936
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