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A suggested positive control is NIH-3T3 cell lysate.
PA5-34408 can be used with blocking peptide PEP-1450.
ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
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Protein Aliases: FYVE domain containing 21; HCV p7-transactivated protein 1; ZF21; Zinc finger FYVE domain-containing protein 21; zinc finger, FYVE domain containing 21
Gene Aliases: 1110013H04Rik; AW558780; C85416; HCVP7TP1; ZF21; ZFYVE21
UniProt ID: (Human) Q9BQ24, (Mouse) Q8VCM3
Entrez Gene ID: (Human) 79038, (Mouse) 68520, (Rat) 362789
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