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ZHX2 Polyclonal Antibody
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Product Details
BS-7581R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ZHX2, amino acids 451-550.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AFP regulator 1; alpha fetoprotein regulation 1, adult; Alpha-fetoprotein regulator 1; Regulator of AFP; transcription factor ZHX2; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes protein 2
Gene Aliases: Afr-1; AFR1; KIAA0854; mKIAA0854; RAF; ZHX2
UniProt ID: (Human) Q9Y6X8, (Rat) Q80VX4, (Mouse) Q8C0C0
Entrez Gene ID: (Human) 22882, (Rat) 314988, (Mouse) 387609
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
protein binding
zinc ion binding
identical protein binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
mRNA catabolic process
nervous system development
central nervous system neuron differentiation
cell differentiation
somatic stem cell population maintenance
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
retinal bipolar neuron differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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