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Invitrogen
ZIC3 Polyclonal Antibody
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Product Details
PA5-29073
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ZIC3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.84 mg/mL
Amount
84 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HepG2.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (93%), Xenopus laevis (92%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heterotaxy 1; transcription factor; ZIC; Zic family member 3 (odd-paired homolog, Drosophila); ZIC1; ZIC2; Zinc finger protein 203; Zinc finger protein of the cerebellum 3; Zinc finger protein ZIC 3; ZNF201
Gene Aliases: HTX; HTX1; RGD1561261; VACTERLX; ZIC3; ZNF203
UniProt ID: (Human) O60481
Entrez Gene ID: (Human) 7547, (Rat) 367944
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
nucleic acid binding
C2H2 zinc finger transcription factor
skeletal system development
neural plate development
heart looping
atrial cardiac muscle tissue development
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
determination of left/right symmetry
gastrulation
pattern specification process
nervous system development
central nervous system development
mesoderm development
heart development
embryonic pattern specification
anterior/posterior pattern specification
gene expression
stem cell population maintenance
hippocampus development
olfactory bulb development
cell differentiation
neuron differentiation
lung development
germ-line stem cell population maintenance
forebrain development
limb morphogenesis
central nervous system segmentation
determination of pancreatic left/right asymmetry
determination of left/right asymmetry in nervous system
outer ear morphogenesis
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
axial mesoderm development
paraxial mesoderm development
stem cell differentiation
face development
left/right pattern formation
left/right axis specification
determination of digestive tract left/right asymmetry
determination of liver left/right asymmetry
primitive streak formation
maintenance of cell number
cranial skeletal system development
transcription from RNA polymerase II promoter
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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