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A suggested positive control is human spleen tissue lysate.
PA5-21064 can be used with blocking peptide PEP-1178.
ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist.
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Protein Aliases: solute carrier family 39 (metal ion transporter), member 10; solute carrier family 39 (zinc transporter), member 10; Solute carrier family 39 member 10; Zinc transporter ZIP10; ZIP-10; Zrt- and Irt-like protein 10
Gene Aliases: 2900042E17Rik; 5430433I10; KIAA1265; LZT-Hs2; mKIAA1265; SLC39A10; ZIP10
Molecular Function: secondary carrier transporter