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Invitrogen
ZIP10 Polyclonal Antibody
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Product Details
PA5-21064
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the center of human ZIP10.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-21064 can be used with blocking peptide PEP-1178.
Target Information
ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: solute carrier family 39 (metal ion transporter), member 10; solute carrier family 39 (zinc transporter), member 10; Solute carrier family 39 member 10; unnamed protein product; zinc transporter 10; Zinc transporter ZIP10; ZIP-10; Zrt- and Irt-like protein 10; ZRT/IRT-like protein 10
Gene Aliases: 2900042E17Rik; 5430433I10; KIAA1265; LZT-Hs2; mKIAA1265; SLC39A10; ZIP10
UniProt ID: (Human) Q9ULF5, (Mouse) Q6P5F6
Entrez Gene ID: (Human) 57181, (Mouse) 227059, (Rat) 363229
epithelial to mesenchymal transition
negative regulation of B cell apoptotic process
ion transport
zinc II ion transport
cellular zinc ion homeostasis
bicarbonate transport
metal ion transport
cellular cation homeostasis
positive regulation of B cell proliferation
positive regulation of B cell receptor signaling pathway
transmembrane transport
zinc II ion transmembrane transport
zinc II ion transmembrane import
transport
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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