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Invitrogen
ZIP12 Polyclonal Antibody
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Product Details
PA5-21075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the amino terminus of human ZIP12.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-21075 can be used with blocking peptide PEP-1189.
Target Information
The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIV-1 subfamily of ZIP zinc transporter 8; LZT-Hs8; solute carrier family 39 (metal ion transporter), member 12; solute carrier family 39 (zinc transporter), member 12; Solute carrier family 39 member 12; unnamed protein product; zinc transporter 12; Zinc transporter ZIP12; ZIP-12; Zrt- and Irt-like protein 12; ZRT/IRT-like protein 12
Gene Aliases: AW046938; bA570F3.1; Gm731; LZT-Hs8; SLC39A12; ZIP-12; ZIP12
UniProt ID: (Human) Q504Y0, (Mouse) Q5FWH7
Entrez Gene ID: (Human) 221074, (Mouse) 277468
neural tube formation
ion transport
zinc II ion transport
signal transduction
regulation of neuron projection development
bicarbonate transport
metal ion transport
cellular cation homeostasis
regulation of microtubule polymerization
transmembrane transport
zinc II ion transmembrane import
neuron projection extension
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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