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Invitrogen
ZIP14 Polyclonal Antibody
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FIGURE: 1 / 5
ZIP14 Antibody (PA5-21077) in IHC
RMD open 2023 -
Osteoarthritis hypertrophic chondrocytes (OAHCs) induced to differentiate by TGFbeta stimulation, and these specific OAHCs, unlike typical hypertrophic chondrocytes, exist in the weight-bearing cartilage surface of joints. (A) Relative expression levels of OAHCs marker genes were assessed in either weight-bearing or non-weight-bearing cartilage tissues (nine knee patients with osteoarthritis (OA) with total... View More
Product Details
PA5-21077
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 16 amino acid synthetic peptide near the center of human ZIP14. The immunogen is located within amino acids 230-280 of ZIP14.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive controls are human liver, mouse kidney, or rat kidney tissue lysates.
PA5-21077 can be used with blocking peptide PEP-1191.
Predicted species reactivity based on immunogen sequence: Bovine: (94%).
At least three isoforms of ZIP14 are known to exist; this antibody will detect all isoforms. ZIP14 antibody is predicted to not cross-react with other ZIP family members.
Target Information
The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Factor for adipocyte differentiation 123; FAD-123; KIAA0062; LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Metal cation symporter ZIP14; solute carrier family 39 (metal ion transporter), member 14; solute carrier family 39 (zinc transporter) member 14 isoform SLC39A14_1; solute carrier family 39 (zinc transporter) member 14 isoform SLC39A14_2; solute carrier family 39 (zinc transporter) member 14 isoform SLC39A14_3; solute carrier family 39 (zinc transporter) member 14 isoform SLC39A14_4; solute carrier family 39 (zinc transporter), member 14; Solute carrier family 39 member 14; unnamed protein product; zinc transporter 14; Zinc transporter ZIP14; ZIP-14; Zrt- and Cig19; Zrt- and Irt-like protein 14; Zrt-, Irt-like protein 14
Gene Aliases: cig19; FAD-123; Fad123; HCIN; HMNDYT2; KIAA0062; LZT-Hs4; NET34; SLC39A14; ZIP-14; ZIP14
UniProt ID: (Human) Q15043, (Mouse) Q75N73
Entrez Gene ID: (Human) 23516, (Rat) 306009, (Mouse) 213053
iron ion transmembrane transporter activity
manganese ion transmembrane transporter activity
zinc ion transmembrane transporter activity
protein binding
cadmium ion transmembrane transporter activity
ferrous iron transmembrane transporter activity
anion:cation symporter activity
metal ion transmembrane transporter activity
monoatomic cation:bicarbonate symporter activity
secondary carrier transporter
chondrocyte differentiation
gluconeogenesis
ion transport
iron ion transport
zinc II ion transport
cellular zinc ion homeostasis
insulin receptor signaling pathway
regulation of hormone levels
bicarbonate transport
metal ion transport
cellular cation homeostasis
cellular response to insulin stimulus
iron assimilation
iron ion transmembrane transport
positive regulation of G-protein coupled receptor protein signaling pathway
manganese ion homeostasis
transmembrane transport
cadmium ion transmembrane transport
cellular response to glucose stimulus
manganese ion transmembrane transport
zinc II ion transmembrane transport
zinc II ion transmembrane import
anion transmembrane transport
inorganic cation transmembrane transport
import across plasma membrane
ferrous iron transport
transport
ferrous iron transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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