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ZIPK Polyclonal Antibody
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FIGURE: 1 / 3
ZIPK Antibody (600-401-GF5) in ICC/IF
Immunocytochemistry of ZIPK antibody. Cells: Jurkat. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: ZIPK antibody at 10 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: ZIPK is membranal. Staining: ZIPK as precipitated brown signal with hematoxylin blue nuclear counterstain.
Product Details
600-401-GF5
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-ZIP kinase antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the internal region of human ZIP kinase.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP kinase 3; DAP-like kinase; DAP3K; death-associated kinase 3; Death-associated like kinase; Death-associated protein kinase 3; Dlk; MYPT1 kinase; unnamed protein product; ZIP kinase; ZIP kinase isoform; ZIP-kinase; Zipper-interacting protein kinase
Gene Aliases: DAPK3; Dapkl; DLK; ZIP; ZIPK
UniProt ID: (Human) O43293, (Rat) O88764, (Mouse) O54784
Entrez Gene ID: (Human) 1613, (Rat) 64391, (Mouse) 13144
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
cAMP response element binding protein binding
kinase activity
transferase activity
small GTPase binding
identical protein binding
protein homodimerization activity
leucine zipper domain binding
protein serine kinase activity
calmodulin-dependent protein kinase activity
Rho GTPase binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
chromatin organization
regulation of transcription, DNA-templated
regulation of translation
protein phosphorylation
apoptotic process
regulation of smooth muscle contraction
regulation of mitotic nuclear division
regulation of mitotic cell cycle
regulation of cell shape
regulation of autophagy
negative regulation of translation
positive regulation of cell migration
regulation of actin cytoskeleton organization
intracellular signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
regulation of myosin II filament organization
protein autophosphorylation
regulation of focal adhesion assembly
cellular response to interferon-gamma
positive regulation of canonical Wnt signaling pathway
apoptotic signaling pathway
regulation of cell motility
transcription, DNA-templated
chromatin modification
neuron differentiation
regulation of actin cytoskeleton reorganization
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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