This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human ZIP Kinase/DAPK3.
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases1. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAP kinase 3; DAP-like kinase; DAP3K; Death-associated protein kinase 3; Dlk; MYPT1 kinase; ZIP-kinase; Zipper-interacting protein kinase
Gene Aliases: DAPK3; DLK; ZIP; ZIPK
UniProt ID: (Human) O43293
Entrez Gene ID: (Human) 1613
Molecular Function: non-receptor serine/threonine protein kinase