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Proteintech
ZMPSTE24 Polyclonal Antibody
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Product Details
12847-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZMPSTE24 Fusion Protein Ag3949 (225-475 aa encoded by BC037283)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KFTPLPEGK LKEEIEVMAK SIDFPLTKVY VVEGSKRSSH SNAYFYGFFK NKRIVLFDTL LEEYSVLNKD IQEDSGMEPR NEEEGNSEEI KAKVKNKKQG CKNEEVLAVL GHELGHWKLG HTVKNIIISQ MNSFLCFFLF AVLIGRKELF AAFGFYDSQP TLIGLLIIFQ FIFSPYNEVL SFCLTVLSRR FEFQADAFAK KLGKAKDLYS ALIKLNKDNL GFPVSDWLFS MWHYSHPPLL ERLQALKTMK QH (225-475 aa encoded by BC037283)
Target Information
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAAX prenyl protease 1 homolog; FACE-1; Farnesylated proteins-converting enzyme 1; FLJ14968; Prenyl protein-specific endoprotease 1; unnamed protein product; zinc metallopeptidase STE24 homolog; Zinc metalloproteinase Ste24 homolog
Gene Aliases: FACE-1; FACE1; HGPS; PRO1; RSDM1; STE24; Ste24p; ZMPSTE24
UniProt ID: (Human) O75844
Entrez Gene ID: (Human) 10269
liver development
hair follicle development
heart morphogenesis
ventricular cardiac muscle tissue development
cardiac ventricle development
growth plate cartilage development
DNA repair
chromatin organization
regulation of transcription, DNA-templated
proteolysis
lipid metabolic process
inflammatory cell apoptotic process
cellular response to DNA damage stimulus
nucleus organization
nuclear envelope organization
regulation of mitotic cell cycle
adult walking behavior
regulation of heart contraction
determination of adult lifespan
regulation of cell shape
epidermis development
regulation of autophagy
positive regulation of gene expression
negative regulation of gene expression
regulation of glucose metabolic process
protein processing
regulation of lipid metabolic process
bone mineralization
prenylated protein catabolic process
regulation of bone mineralization
regulation of TOR signaling
regulation of hormone metabolic process
multicellular organism growth
regulation of multicellular organism growth
regulation of gene expression, epigenetic
maintenance of rDNA
regulation of DNA damage response, signal transduction by p53 class mediator
hypomethylation of CpG island
regulation of fibroblast proliferation
thymus development
regulation of defense response to virus
neuromuscular process
chromosome organization
protein maturation
cardiac muscle cell development
regulation of ventricular cardiac muscle cell membrane repolarization
kidney morphogenesis
cardiac conduction
CAMKK-AMPK signaling cascade
regulation of stress-activated protein kinase signaling cascade
cellular response to gamma radiation
CAAX-box protein processing
response to DNA damage checkpoint signaling
regulation of mitotic cell cycle DNA replication
regulation of blood circulation
negative regulation of production of miRNAs involved in gene silencing by miRNA
calcium ion import into sarcoplasmic reticulum
regulation of termination of RNA polymerase I transcription
regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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