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Product Details
PA5-21090
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.125-0.25 µg/mL | - |
Immunocytochemistry (ICC/IF) |
10 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A 17 amino acid peptide near the amino terminus of human ZMYM2 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_11152210 |
Product Specific Information
A suggested positive control is rat lung tissue lysate.
PA5-21090 can be used with blocking peptide PEP-1204.
The immunogen is located within amino acids 120 - 170 of ZMYM2.
Target Information
ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fused in myeloproliferative disorders protein; rearranged in an atypical myeloproliferative disorder; Rearranged in atypical myeloproliferative disorder protein; RP11-264J4.7; Zinc finger MYM-type protein 2; Zinc finger protein 198; zinc finger, MYM-type 2
Gene Aliases: 5830413P05Rik; FIM; MYM; RAMP; SCLL; Zfp198; ZMYM2; ZNF198
UniProt ID: (Human) Q63HP0, (Mouse) Q9CU65
Entrez Gene ID: (Human) 7750, (Mouse) 76007, (Rat) 305913
Molecular Function:
zinc finger transcription factor
Performance Guarantee
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