Proteintech

ZNF238 Polyclonal Antibody

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ZNF238 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 12714-1-AP ( ZNF238 Antibody) at dilution of 1:50 (under 40x lens).

ZNF238 Antibody in Western Blot (WB) — Mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Immunoprecipitation (IP) — IP result of anti-ZNF238 (12714-1-AP for IP and Detection) with mouse cerebellum tissue.

Product Details

12714-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2400	-
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	-	View 1 publication 1 publication
Immunoprecipitation (IP)	0.5-4.0 µg	-
ChIP assay (ChIP)	Assay-dependent	View 1 publication 1 publication
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	ZNF238 Fusion Protein Ag3406 (323-522 aa encoded by BC036677) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.54 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: LAPLREDSV LRELDREDKA SDDEMMTPES ERVQVEGGME SSLLPYVSNI LSPAGQIFMC PLCNKVFPSP HILQIHLSTH FREQDGIRSK PAADVNVPTC SLCGKTFSCM YTLKRHERTH SGEKPYTCTQ CGKSFQYSHN LSRHAVVHTR EKPHACKWCE RRFTQSGDLY RHIRKFHCEL VNSLSVKSEA LSLPTVRDWT L (323-522 aa encoded by BC036677)

Target Information

ZNF238 is the sequence-specific DNA-binding protein with transcriptional repression activity. ZNF238 binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core. ZNF238 may play a role in the organization of chromosomes in the nucleus.C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.

Neuron

Cargnin F,Kwon JS,Katzman S,Chen B,Lee JW,Lee SK

Wed Dec 05 00:00:00 EST 2018

Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.

PLoS biology

Sagner A,Gaber ZB,Delile J,Kong JH,Rousso DL,Pearson CA,Weicksel SE,Melchionda M,Mousavy Gharavy SN,Briscoe J,Novitch BG

Thu Feb 01 00:00:00 EST 2018

Rp58 and p27^kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

Neural development

Clément O,Hemming IA,Gladwyn-Ng IE,Qu Z,Li SS,Piper M,Heng JI

Mon May 15 00:00:00 EDT 2017

The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.

Cerebral cortex (New York, N.Y. : 1991)

Heng JI,Qu Z,Ohtaka-Maruyama C,Okado H,Kasai M,Castro D,Guillemot F,Tan SS

Sun Mar 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: 58 kDa repressor protein; rRP58; TAZ-1; Transcriptional repressor RP58; Translin-associated zinc finger protein 1; Zfp-238; Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238; Zinc finger protein C2H2-171

Gene Aliases: C2H2-171; MRD22; RP58; TAZ-1; TAZ1; ZBTB18; Zfp238; ZNF238

UniProt ID: (Human) Q99592, (Mouse) Q9WUK6, (Rat) Q9JKY3

Entrez Gene ID: (Human) 10472, (Mouse) 30928, (Rat) 64619

Molecular Function: C2H2 zinc finger transcription factor