Proteintech

ZNF238 Polyclonal Antibody

View all (9) ZNF238 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (19)

ZNF238 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ZNF238 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 19

ZNF238 Antibody (12714-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 12714-1-AP ( ZNF238 Antibody) at dilution of 1:50 (under 40x lens).

ZNF238 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ZNF238 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Western Blot (WB)

ZNF238 Antibody in Immunoprecipitation (IP)

Product Image Gallery

ZNF238 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 12714-1-AP ( ZNF238 Antibody) at dilution of 1:50 (under 40x lens).

ZNF238 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 12714-1-AP (ZNF238 Antibody) at dilution of 1:50 (under 10x lens).

ZNF238 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 12714-1-AP) ZNF238 antibody at dilution of 1:5,000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 12714-1-AP (ZNF238 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ZNF238 Antibody in Immunoprecipitation (IP) — IP result of anti-ZNF238 (12714-1-AP for IP and Detection) with mouse cerebellum tissue.

Product Details

12714-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 4 publications 4 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

-

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

ChIP assay (ChIP)

Assay-dependent

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ZNF238 Fusion Protein Ag3406 (323-522 aa encoded by BC036677)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.54 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LAPLREDSV LRELDREDKA SDDEMMTPES ERVQVEGGME SSLLPYVSNI LSPAGQIFMC PLCNKVFPSP HILQIHLSTH FREQDGIRSK PAADVNVPTC SLCGKTFSCM YTLKRHERTH SGEKPYTCTQ CGKSFQYSHN LSRHAVVHTR EKPHACKWCE RRFTQSGDLY RHIRKFHCEL VNSLSVKSEA LSLPTVRDWT L (323-522 aa encoded by BC036677)

Target Information

ZNF238 is the sequence-specific DNA-binding protein with transcriptional repression activity. ZNF238 binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core. ZNF238 may play a role in the organization of chromosomes in the nucleus.C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats.

Journal of pineal research

Yang H,Zhang Z,Ding X,Jiang X,Tan L,Lin C,Xu L,Li G,Lu L,Qin Z,Feng X,Li M

Tue Aug 01 00:00:00 UTC 2023

RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats.

Journal of pineal research

Yang H,Zhang Z,Ding X,Jiang X,Tan L,Lin C,Xu L,Li G,Lu L,Qin Z,Feng X,Li M

Tue Aug 01 00:00:00 UTC 2023

ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.

Science advances

Wang R,Bhatt AB,Minden-Birkenmaier BA,Travis OK,Tiwari S,Jia H,Rosikiewicz W,Martinot O,Childs E,Loesch R,Tossou G,Jamieson S,Finkelstein D,Xu B,Labelle M

Fri Jan 06 00:00:00 UTC 2023

ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.

Science advances

Wang R,Bhatt AB,Minden-Birkenmaier BA,Travis OK,Tiwari S,Jia H,Rosikiewicz W,Martinot O,Childs E,Loesch R,Tossou G,Jamieson S,Finkelstein D,Xu B,Labelle M

Fri Jan 06 00:00:00 UTC 2023

ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.

Science advances

Wang R,Bhatt AB,Minden-Birkenmaier BA,Travis OK,Tiwari S,Jia H,Rosikiewicz W,Martinot O,Childs E,Loesch R,Tossou G,Jamieson S,Finkelstein D,Xu B,Labelle M

Fri Jan 06 00:00:00 UTC 2023

ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.

Science advances

Wang R,Bhatt AB,Minden-Birkenmaier BA,Travis OK,Tiwari S,Jia H,Rosikiewicz W,Martinot O,Childs E,Loesch R,Tossou G,Jamieson S,Finkelstein D,Xu B,Labelle M

Fri Jan 06 00:00:00 UTC 2023

ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.

Science advances

Wang R,Bhatt AB,Minden-Birkenmaier BA,Travis OK,Tiwari S,Jia H,Rosikiewicz W,Martinot O,Childs E,Loesch R,Tossou G,Jamieson S,Finkelstein D,Xu B,Labelle M

Fri Jan 06 00:00:00 UTC 2023

ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.

Science advances

Wang R,Bhatt AB,Minden-Birkenmaier BA,Travis OK,Tiwari S,Jia H,Rosikiewicz W,Martinot O,Childs E,Loesch R,Tossou G,Jamieson S,Finkelstein D,Xu B,Labelle M

Fri Jan 06 00:00:00 UTC 2023

ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma.

Life science alliance

Ferrarese R,Izzo A,Andrieux G,Lagies S,Bartmuss JP,Masilamani AP,Wasilenko A,Osti D,Faletti S,Schulzki R,Yuan S,Kling E,Ribecco V,Heiland DH,Tholen S,Prinz M,Pelicci G,Kammerer B,Boerries M,Carro MS

Sun Jan 01 00:00:00 UTC 2023

Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism.

iScience

Masilamani AP,Schulzki R,Yuan S,Haase IV,Kling E,Dewes F,Andrieux G,Börries M,Schnell O,Heiland DH,Schilling O,Ferrarese R,Carro MS

Fri Jul 15 00:00:00 UTC 2022

Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism.

iScience

Masilamani AP,Schulzki R,Yuan S,Haase IV,Kling E,Dewes F,Andrieux G,Börries M,Schnell O,Heiland DH,Schilling O,Ferrarese R,Carro MS

Fri Jul 15 00:00:00 UTC 2022

Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex.

Human mutation

Hemming IA,Clément O,Gladwyn-Ng IE,Cullen HD,Ng HL,See HB,Ngo L,Ulgiati D,Pfleger KDG,Agostino M,Heng JI

Tue Oct 01 00:00:00 UTC 2019

FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.

Neuron

Cargnin F,Kwon JS,Katzman S,Chen B,Lee JW,Lee SK

Wed Dec 05 00:00:00 UTC 2018

FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.

Neuron

Cargnin F,Kwon JS,Katzman S,Chen B,Lee JW,Lee SK

Wed Dec 05 00:00:00 UTC 2018

Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.

PLoS biology

Sagner A,Gaber ZB,Delile J,Kong JH,Rousso DL,Pearson CA,Weicksel SE,Melchionda M,Mousavy Gharavy SN,Briscoe J,Novitch BG

Thu Feb 01 00:00:00 UTC 2018

Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.

PLoS biology

Sagner A,Gaber ZB,Delile J,Kong JH,Rousso DL,Pearson CA,Weicksel SE,Melchionda M,Mousavy Gharavy SN,Briscoe J,Novitch BG

Thu Feb 01 00:00:00 UTC 2018

Rp58 and p27^kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

Neural development

Clément O,Hemming IA,Gladwyn-Ng IE,Qu Z,Li SS,Piper M,Heng JI

Mon May 15 00:00:00 UTC 2017

Rp58 and p27^kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

Neural development

Clément O,Hemming IA,Gladwyn-Ng IE,Qu Z,Li SS,Piper M,Heng JI

Mon May 15 00:00:00 UTC 2017

The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.

Cerebral cortex (New York, N.Y. : 1991)

Heng JI,Qu Z,Ohtaka-Maruyama C,Okado H,Kasai M,Castro D,Guillemot F,Tan SS

Sun Mar 01 00:00:00 UTC 2015

The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.

Cerebral cortex (New York, N.Y. : 1991)

Heng JI,Qu Z,Ohtaka-Maruyama C,Okado H,Kasai M,Castro D,Guillemot F,Tan SS

Sun Mar 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 58 kDa repressor protein; rRP58; TAZ-1; Transcriptional repressor RP58; Translin-associated zinc finger protein 1; Zfp-238; Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238; Zinc finger protein C2H2-171

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Gene Aliases: C2H2-171; MRD22; RP58; TAZ-1; TAZ1; ZBTB18; Zfp238; ZNF238

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UniProt ID: (Human) Q9UD99, (Mouse) Q9WUK6, (Rat) Q9JKY3

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Entrez Gene ID: (Human) 10472, (Mouse) 30928, (Rat) 64619

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DNA binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding metal ion binding nucleic acid binding C2H2 zinc finger transcription factor

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated skeletal muscle tissue development negative regulation of transcription, DNA-templated in utero embryonic development regulation of transcription, DNA-templated multicellular organism development cerebellum development hippocampus development cerebral cortex development neuron development homeostasis of number of cells regulation of cell division

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