ZNF306 is a protein coding gene. Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: SCAN-KRAB-zinc finger gene 1; SCAN-KRAB-zinc finger protein; Zf47; Zinc finger and SCAN domain-containing protein 13; Zinc finger protein 306; Zinc finger protein 307; Zinc finger protein 309; Zinc finger protein 47 homolog; Zinc finger protein with KRAB and SCAN domains 3; zinc finger protein zfp47
Gene Aliases: 2810435N07Rik; AA408594; AI132359; dJ874C20.1; dJ874C20.1.; mszf35; Skz1; ZF47; Zfp-47; ZFP306; Zfp307; ZFP47; ZKSCAN3; ZNF306; ZNF309; ZSCAN13; ZSCAN35
Molecular Function: nucleic acid binding