ZNF446 contains a KRAB and three C(2)H(2) zinc fingers. ZNF446 is a transcription repressor when fused to GAL4 DNA-binding domain and co-transfected with VP-16. Overexpression of ZNF446 in COS-7 cells inhibits the transcriptional activities of SRE.
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Protein Aliases: FLJ20626; Zinc finger protein 446; Zinc finger protein with KRAB and SCAN domains 20
Gene Aliases: ZKSCAN20; ZNF446; ZSCAN30; ZSCAN52
UniProt ID: (Human) Q9NWS9
Entrez Gene ID: (Human) 55663
Molecular Function: C2H2 zinc finger transcription factor