Recommended positive controls: HL-60, NCI-H929.
Predicted reactivity: Human (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C6orf149; E3 ubiquitin-protein ligase ZNF598; FLJ00086; ISD11; Zinc finger protein 598
Gene Aliases: ZNF598
UniProt ID: (Human) Q86UK7
Entrez Gene ID: (Human) 90850