FIGURE: 1 / 1
Immunogen sequence: VVGGEDYEEV DRYSRQGRVA RAGTRGAQQS RRGSWRYKRE EEDREVAAAV RASVAAQQQE EARRSEDQEE GGRPKKEEAA ARGPEDPRGP RRSPRTQGEG PGPKETSTNG PVSQ
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 78%.
ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.