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Proteintech
ZNF638 Polyclonal Antibody
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Product Details
31300-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZNF638 fusion protein Ag35296
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Amount
67.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VDEVGEEEDG DNDLKVELAQ SKNDHPTDKK GNRKKRAVDT KKTKLESLSQ VGPVNENVME EDLKTMIERH LTAKTPTKRV RIGKTLPSEK AVVTEPAKGE EAFQMSEVDE ESGLKDSEPE RKRKKTEDSS SGKSVASDVP EELDFLVPKA GFFCPICSLF YSGEKAMTNH CKSTRHKQNT EKFMAKQRKE KEQNEAEERS SR
Target Information
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. NP220 (Nuclear protein 220), also designated Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein that contains one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation. NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines. NP220 interacts with FHL-2 and is also thought to be phosphorylated by ATM or ATR upon DNA damage. It exists as five isoforms as a result of alternative splicing events. Isoform five of NP220 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTCL tumor antigen se33-1; CTCL-associated antigen se33-1; Cutaneous T-cell lymphoma-associated antigen se33-1; NP220 nuclear protein; Nuclear protein 220; unnamed protein product; Zinc finger matrin-like protein; Zinc finger protein 638
Gene Aliases: NP220; ZFML; Zfp638; ZNF638
UniProt ID: (Human) Q14966
Entrez Gene ID: (Human) 27332
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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