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Proteintech
ZNHIT2 Polyclonal Antibody
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Product Details
16885-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZNHIT2 Fusion Protein Ag10351 (1-403 aa encoded by BC052240)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEPAGPCGF CPAGEVQPAR YTCPRCNAPY CSLRCYRTHG TCAENFYRDQ VLGELRGCSA PPSRLASALR RLRQQRETED EPGEAGLSSG PAPGGLSGLW ERLAPGEKAA FERLLSRGEA GRLLPPWRPW WWNRGAGPQL LEELDNAPGS DAAELELAPA RTPPDSVKDA SAAEPAAAER VLGDVPGACT PVVPTRIPAI VSLSRGPVSP LVRFQLPNVL FAYAHTLALY HGGDDALLSD FCATLLGVSG ALGAQQVFAS AEEALQAAAH VLEAGEHPPG PLGTRGAMHE VARILLGEGP TNQKGYTLAA LGDLAQTLGR ARKQAVAREE RDHLYRARKK CQFLLAWTNE NEAALTPLAL DCARAHQAHA VVAEEVAALT GELERLWGGP VPPAPRTLIE ELPS (1-403 aa encoded by BC052240)
Target Information
The ZNHIT2 gene, located on chromosome 7, encodes a zinc-finger HIT-type containing protein crucial for various cellular processes, such as chromatin remodeling and gene transcription regulation. Knockout studies in mice reveal that ZNHIT2, alongside ZNHIT1, is essential during early development, with deficits leading to embryonic lethality during peri-implantation stages due to reduced proportions of pluripotent inner cell mass cells and aberrant expression of key developmental genes like NANOG and SOX17. This gene's relevance extends to its involvement in protein-protein and protein-nucleic acid interactions that are fundamental in cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FON protein; Protein FON; Zinc finger HIT domain-containing protein 2; zinc finger, HIT domain containing 2; zinc finger, HIT domain containing 2, pseudogene; zinc finger, HIT type 2
Gene Aliases: C11orf5; FON; ORF6; RGD1307918; ZNHIT2; Znhit2-ps
UniProt ID: (Human) Q9UHR6, (Mouse) Q9QY66
Entrez Gene ID: (Human) 741, (Rat) 309177, (Mouse) 29805
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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