Keep as concentrated solution.
Positive Control: 293T, A431, HeLa, HepG2, A549, H1299, HCT116, mouse testis.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp686M05161 antibody; MGC133289 antibody; Tight junction protein 1; tight junction protein 1 (zona occludens 1) antibody; Tight junction protein ZO-1; tight junction protein ZO-1 antibody; TJP1 antibody; ZO-1 antibody; zona occludens 1; zona occludens 1 antibody; Zona occludens protein 1; zona occludens protein 1 antibody; zonula occludens 1 protein; zonula occludens 1 protein antibody; Zonula occludens protein 1; zonula occludens protein 1 antibody
Gene Aliases: TJP1; ZO-1; ZO1