This antibody reacts with an internal region of the ZONAB protein. On Western blots, it identifies a major band at ~65 kDa and a minor band at ~54 kDa. The antibody is directed towards a region of ZONAB common to both the long and the alternatively-spliced short form. During development, reactivity was confirmed using mouse testis tissue homogenates by Western blotting and labeling of mouse testis tissue using immunofluorescence. All signals were absent in knockout mice, further confirming the reactivity with ZONAB.
Human DNA-binding protein (dbpA) is a member of a Y-box binding protein family containing a cold shock domain. The increased expression of Y box binding proteins in somatic cells is associated with cell proliferation and transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cold shock domain protein A; Cold shock domain-containing protein A; DNA-binding protein A; Muscle Y-box protein YB2; RYB-A; Y-box protein 3; Y-box-binding protein 3; Y-box-binding protein A; ZONAB A; ZONAB B
Gene Aliases: Csda; Dbpa; Dpba; MSY3; MSY4; oxyR; Yb2; Ybx3