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Invitrogen
ZONAB Polyclonal Antibody
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Product Details
40-2800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
C. elegans,
Dog,
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from an internal region of mouse ZONAB (ZO-1 associated nucleic acid-binding protein
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with an internal region of the ZONAB protein. On Western blots, it identifies a major band at ~65 kDa and a minor band at ~54 kDa. The antibody is directed towards a region of ZONAB common to both the long and the alternatively-spliced short form. During development, reactivity was confirmed using mouse testis tissue homogenates by Western blotting and labeling of mouse testis tissue using immunofluorescence. All signals were absent in knockout mice, further confirming the reactivity with ZONAB.
Target Information
Human DNA-binding protein (dbpA) is a member of a Y-box binding protein family containing a cold shock domain. The increased expression of Y box binding proteins in somatic cells is associated with cell proliferation and transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cold shock domain protein A; Cold shock domain-containing protein A; DNA-binding protein A; Muscle Y-box protein YB2; RYB-A; Y-box protein 3; Y-box-binding protein 3; Y-box-binding protein A; ZONAB A; ZONAB B
Gene Aliases: Csda; Dbpa; Dpba; MSY3; MSY4; oxyR; Yb2; Ybx3
UniProt ID: (Rat) Q62764, (Mouse) Q9JKB3
Entrez Gene ID: (Rat) 83807, (Mouse) 56449
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
single-stranded DNA binding
mRNA 3'-UTR binding
poly(A) RNA binding
nucleic acid binding
RNA binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
spermatogenesis
male gonad development
fertilization
organ regeneration
negative regulation of apoptotic process
positive regulation of organ growth
negative regulation of skeletal muscle tissue development
negative regulation of necroptotic process
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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