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Product Details
PA5-58998
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ZPK. Recombinant protein control fragment (Product #RP-89788).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2650395
Product Specific Information
Immunogen sequence: GAKGEPPPPV GPGEGVGLLG TGREGTSGRG GSRAGSQHLT PAALLYRAAV TRSQKRGISS EEEEGEVDSE VELTSSQRWP QSLNMRQSLS TFSSENPSDG EEGTASEPSP SGTPEVGSTN TDERPDERSD DMCSQGSEIP LDP^M
^M
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DLK; Dual leucine zipper bearing kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; Leucine-zipper protein kinase; M3KC; MAPK-upstream kinase; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; protein kinase MUK; ZPK
Gene Aliases: DLK; MAP3K12; MEKK12; MUK; ZPK; ZPKP1
UniProt ID: (Human) Q12852
Entrez Gene ID: (Human) 7786
activation of MAPKK activity
protein phosphorylation
JNK cascade
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
intracellular signal transduction
protein autophosphorylation
mitophagy in response to mitochondrial depolarization
negative regulation of motor neuron apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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