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Invitrogen
ZPR1 Polyclonal Antibody
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FIGURE: 1 / 1
ZPR1 Antibody (PA5-90668) in WB
Western blot analysis of ZPR1 in extracts of U-87MG cells. Samples were incubated with ZPR1 Polyclonal antibody (Product # PA5-90668) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-90668
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 110-459 of human ZPR1 (NP_0038951)
Conjugate
Form
Liquid
Concentration
1.07 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LEDMNREVVK TDSAATRIPE LDFEIPAFSQ KGALTTVEGL ITRAISGLEQ DQPARRANKD ATAERIDEFI VKLKELKQVA SPFTLIIDDP SGNSFVENPH APQKDDALVI THYNRTRQQE EMLGLQEEAP AEKPEEEDLR NEVLQFSTNC PECNAPAQTN MKLVQIPHFK EVIIMATNCE NCGHRTNEVK SGGAVEPLGT RITLHITDAS DMTRDLLKSE TCSVEIPELE FELGMAVLGG KFTTLEGLLK DIRELVTKNP FTLGDSSNPG QTERLQEFSQ KMDQIIEGNM KAHFIMDDPA GNSYLQNVYA PEDDPEMKVE RYKRTFDQNE ELGLNDMKTE GYEAGLAPQR; Positive Samples: U-87MG; Cellular Location: Cajal body, Cell projection, Cytoplasm, Nucleus, axon, gem, growth cone, nucleolus, perinuclear region
Target Information
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Zinc finger protein 259; Zinc finger protein ZPR1
Gene Aliases: ZNF259; ZPR1
UniProt ID: (Human) O75312
Entrez Gene ID: (Human) 8882
microtubule cytoskeleton organization
inner cell mass cell proliferation
trophectodermal cell proliferation
mRNA processing
signal transduction
cell proliferation
RNA splicing
positive regulation of gene expression
spinal cord development
Cajal body organization
regulation of myelination
positive regulation of RNA splicing
DNA endoreduplication
positive regulation of protein import into nucleus
positive regulation of growth
axon development
cellular response to epidermal growth factor stimulus
positive regulation of transcription involved in G1/S transition of mitotic cell cycle
apoptotic process involved in development
pre-mRNA catabolic process
negative regulation of motor neuron apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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