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Proteintech
ZRANB3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
23111-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZRANB3 Fusion Protein Ag19407 (728-1079 aa encoded by BC064616)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LPVYDTLMF CASRNTDRIH IYTKDGKQMS CNFIPLDIKL DLWEDLPASF QLKQYRSLIL RFVREWSSLT AMKQRIIRKS GQLFCSPILA LEEITKQQTK QNCTKRYITK EDVAVASMDK VKNVGGHVRL ITKESRPRDP FTKKLLEDGA CVPFLNPYTV QADLTVKPST SKGYLQAVDN EGNPLCLRCQ QPTCQTKQAC KANSWDSRFC SLKCQEEFWI RSNNSYLRAK VFETEHGVCQ LCNVNAQELF LRLRDAPKSQ RKNLLYATWT SKLPLEQLNE MIRNPGEGHF WQVDHIKPVY GGGGQCSLDN LQTLCTVCHK ERTARQAKER SQVRRQSLAS KHGSDITRFL VKK (728-1079 aa encoded by B C064616)
Target Information
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: annealing helicase 2; unnamed protein product; zinc finger Ran-binding domain-containing protein 3; zinc finger, RAN-binding domain containing 3
Gene Aliases: 4933425L19Rik; AH2
UniProt ID: (Human) Q5FWF4
Entrez Gene ID: (Human) 84083
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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