Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAHNPNMTHL KINLPVTALP PLWVRCDSSD PEGTCWLGAE LITTNNSITG IVLYVVSCKA DKNYSVNLEN LKNLHKKRHH LSTVTSKGFA QYELFKSSAL DDTITASQTA IALDISWSPV DEILQIPPLS STATLNIKVE SGEPRGPLNH LYRELKFLLV LADGLRTGVT EWLEPLEAKS AVELVQEFLN DLNKLDGFGD STKKDTEVET LKHDTAAVDR SVKRLFKVRS DLDFAEQLWC KMSSSVISYQ DLVKCFTLII QSLQRGDIQP WLHSGSNSLL SKLIHQSYHG TMDTVSLSGT IPVQMLLEIG LDKLKKDYIS FFIGQELASL NHLEYFIAPS VDIQEQVYRV QKLHHILEIL VSCMPFIKSQ HELLFSLTQI CIKYYKQNPL DEQHIFQLPV RPTAVKNLYQ SEKPQKWRVE IYSGQKKIKT VWQLSDSSPI DHLNFHKPDF SELTLNGSLE ERIFFTNMVT CSQVHFK
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homolog of Drosophila Zwilch; hZwilch; Protein zwilch homolog; Zwilch, kinetochore associated, homolog
Gene Aliases: hZwilch; KNTC1AP; ZWILCH
UniProt ID: (Human) Q9H900
Entrez Gene ID: (Human) 55055
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